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Based on this report, Migaya et al 21 , hypothesized that reduced -oxidation secondary to lower CPT1B expression, would be able to reduce the hypocretin activity, predisposing to narcolepsy

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This metabolic reprogramming constitutes a central node connecting catabolic nutrient breakdown to anabolic biosynthesis by integrating upstream amino acid deamination and transamination reactions with downstream pathways, generating key intermediates including -ketoglutarate, coenzyme A, and citrate that concurrently fuel the tricarboxylic acid cycle and macromolecular synthesis

NAC was dosed at 200 or 300 mg/kg via intraperitoneal injection at 1 h after treatment with 600 mg/kg APAP

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